Semisynthesis and Biological Evaluation of Platencin Thioether Derivatives: Dual FabF and FabH Inhibitors against MRSA

[Image: see text] The discovery and clinical use of multitarget monotherapeutic antibiotics is regarded as a promising approach to reduce the development of antibiotic resistance. Platencin (PTN), a potent natural antibiotic initially isolated from a soil actinomycete, targets both FabH and FabF, th...

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Veröffentlicht in:ACS Med Chem Lett
Hauptverfasser: Li, Yuling, Weng, Xiang, Deng, Youchao, Pan, Jian, Zhu, Saibin, Wen, Zhongqing, Yuan, Yanqiu, Li, Shaowen, Shen, Ben, Duan, Yanwen, Huang, Yong
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2021
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7957939/
https://ncbi.nlm.nih.gov/pubmed/33738071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00653
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