Apicidin: A novel antiprotozoal agent that inhibits parasite histone deacetylase

A novel fungal metabolite, apicidin [cyclo(N-O-methyl-l-tryptophanyl-l-isoleucinyl-d-pipecolinyl-l-2-amino-8-oxodecanoyl)], that exhibits potent, broad spectrum antiprotozoal activity in vitro against Apicomplexan parasites has been identified. It is also orally and parenterally active in vivo again...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Darkin-Rattray, Sandra J., Gurnett, Anne M., Myers, Robert W., Dulski, Paula M., Crumley, Tami M., Allocco, John J., Cannova, Christine, Meinke, Peter T., Colletti, Steven L., Bednarek, Maria A., Singh, Sheo B., Goetz, Michael A., Dombrowski, Anne W., Polishook, Jon D., Schmatz, Dennis M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The National Academy of Sciences of the USA 1996
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC24060/
https://ncbi.nlm.nih.gov/pubmed/8917558
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