Apicidin: A novel antiprotozoal agent that inhibits parasite histone deacetylase

A novel fungal metabolite, apicidin [cyclo(N-O-methyl-l-tryptophanyl-l-isoleucinyl-d-pipecolinyl-l-2-amino-8-oxodecanoyl)], that exhibits potent, broad spectrum antiprotozoal activity in vitro against Apicomplexan parasites has been identified. It is also orally and parenterally active in vivo again...

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Detalhes bibliográficos
Main Authors: Darkin-Rattray, Sandra J., Gurnett, Anne M., Myers, Robert W., Dulski, Paula M., Crumley, Tami M., Allocco, John J., Cannova, Christine, Meinke, Peter T., Colletti, Steven L., Bednarek, Maria A., Singh, Sheo B., Goetz, Michael A., Dombrowski, Anne W., Polishook, Jon D., Schmatz, Dennis M.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences of the USA 1996
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC24060/
https://ncbi.nlm.nih.gov/pubmed/8917558
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