Atividade dos promotores de PARP e VSG na forma procíclica do trypanosoma brucei /

por Ürményi, Turán Péter., Van der Ploeg, Lex H. T.
Publicado em 1995

Magel2‐null mice are hyper‐responsive to setmelanotide, a melanocortin 4 receptor agonist

por Bischof, Jocelyn M, Van Der Ploeg, Lex H T, Colmers, William F, Wevrick, Rachel
Publicado no Br J Pharmacol (2016)

The β-Amyloid Precursor Protein of Alzheimer’s Disease Enhances Neuron Viability and Modulates Neuronal Polarity

por Perez, Ruth G., Zheng, Hui, Van der Ploeg, Lex H. T., Koo, Edward H.
Publicado no J Neurosci (1997)

Temporal cAMP Signaling Selectivity by Natural and Synthetic MC4R Agonists

por Molden, Brent M., Cooney, Kimberly A., West, Kirk, Van Der Ploeg, Lex H. T., Baldini, Giulia
Publicado no Mol Endocrinol (2015)

Differentiation of antiinflammatory and antitumorigenic properties of stabilized enantiomers of thalidomide analogs

por Jacques, Vincent, Czarnik, Anthony W., Judge, Thomas M., Van der Ploeg, Lex H. T., DeWitt, Sheila H.
Publicado no Proc Natl Acad Sci U S A (2015)

The Pentapeptide RM-131 Promotes Food Intake and Adiposity in Wildtype Mice but Not in Mice Lacking the Ghrelin Receptor

por Fischer, Katrin, Finan, Brian, Clemmensen, Christoffer, van der Ploeg, Lex H. T., Tschöp, Matthias H., Müller, Timo D.
Publicado no Front Nutr (2015)

Current Mechanistic and Pharmacodynamic Understanding of Melanocortin-4 Receptor Activation

por Sharma, Shubh, Garfield, Alastair S., Shah, Bhavik, Kleyn, Patrick, Ichetovkin, Ilia, Moeller, Ida Hatoum, Mowrey, William R., Van der Ploeg, Lex H.T.
Publicado no Molecules (2019)

Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance

por Gloaguen, Isabelle, Costa, Patrizia, Demartis, Anna, Lazzaro, Domenico, Di Marco, Annalise, Graziani, Rita, Paonessa, Giacomo, Chen, Fang, Rosenblum, Charles I., Van der Ploeg, Lex H. T., Cortese, Riccardo, Ciliberto, Gennaro, Laufer, Ralph
Publicado em 1997

RM-493, a Melanocortin-4 Receptor (MC4R) Agonist, Increases Resting Energy Expenditure in Obese Individuals

por Chen, Kong Y., Muniyappa, Ranganath, Abel, Brent S., Mullins, Katherine P., Staker, Pamela, Brychta, Robert J., Zhao, Xiongce, Ring, Michael, Psota, Tricia L., Cone, Roger D., Panaro, Brandon L., Gottesdiener, Keith M., Van der Ploeg, Lex H.T., Reitman, Marc L., Skarulis, Monica C.
Publicado no J Clin Endocrinol Metab (2015)

Neither Agouti-Related Protein nor Neuropeptide Y Is Critically Required for the Regulation of Energy Homeostasis in Mice

por Qian, Su, Chen, Howard, Weingarth, Drew, Trumbauer, Myrna E., Novi, Dawn E., Guan, Xiaoming, Yu, Hong, Shen, Zhu, Feng, Yue, Frazier, Easter, Chen, Airu, Camacho, Ramon E., Shearman, Lauren P., Gopal-Truter, Shobhna, MacNeil, Douglas J., Van der Ploeg, Lex H. T., Marsh, Donald J.
Publicado em 2002

Melanocortin 4 Receptor Pathway Dysfunction in Obesity: Patient Stratification Aimed at MC4R Agonist Treatment

por Ayers, Kristin L, Glicksberg, Benjamin S, Garfield, Alastair S, Longerich, Simonne, White, Joseph A, Yang, Pengwei, Du, Lei, Chittenden, Thomas W, Gulcher, Jeffery R, Roy, Sophie, Fiedorek, Fred, Gottesdiener, Keith, Cohen, Sarah, North, Kari E, Schadt, Eric E, Li, Shuyu D, Chen, Rong, Van der Ploeg, Lex H T
Publicado no J Clin Endocrinol Metab (2018)

A neuropeptide Y Y5 antagonist selectively ameliorates body weight gain and associated parameters in diet-induced obese mice

por Ishihara, Akane, Kanatani, Akio, Mashiko, Satoshi, Tanaka, Takeshi, Hidaka, Masayasu, Gomori, Akira, Iwaasa, Hisashi, Murai, Naomi, Egashira, Shin-ichiro, Murai, Takashi, Mitobe, Yuko, Matsushita, Hiroko, Okamoto, Osamu, Sato, Nagaaki, Jitsuoka, Makoto, Fukuroda, Takahiro, Ohe, Tomoyuki, Guan, Xiaoming, MacNeil, Douglas J., Van der Ploeg, Lex H. T., Nishikibe, Masaru, Ishii, Yasuyuki, Ihara, Masaki, Fukami, Takehiro
Publicado em 2006

Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism

por Marsh, Donald J., Weingarth, Drew T., Novi, Dawn E., Chen, Howard Y., Trumbauer, Myrna E., Chen, Airu S., Guan, Xiao-Ming, Jiang, Michael M., Feng, Yue, Camacho, Ramon E., Shen, Zhu, Frazier, Easter G., Yu, Hong, Metzger, Joseph M., Kuca, Stephanie J., Shearman, Lauren P., Gopal-Truter, Shobhna, MacNeil, Douglas J., Strack, Alison M., MacIntyre, D. Euan, Van der Ploeg, Lex H. T., Qian, Su
Publicado em 2002

Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R

por Sailer, Andreas W., Sano, Hideki, Zeng, Zhizhen, McDonald, Terrence P., Pan, Jie, Pong, Sheng-Shung, Feighner, Scott D., Tan, Carina P., Fukami, Takehiro, Iwaasa, Hisashi, Hreniuk, Donna L., Morin, Nancy R., Sadowski, Sharon J., Ito, Makoto, Ito, Masahiko, Bansal, Alka, Ky, Betty, Figueroa, David J., Jiang, Qingping, Austin, Christopher P., MacNeil, Douglas J., Ishihara, Akane, Ihara, Masaki, Kanatani, Akio, Van der Ploeg, Lex H. T., Howard, Andrew D., Liu, Qingyun
Publicado em 2001

Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency

por Collet, Tinh-Hai, Dubern, Béatrice, Mokrosinski, Jacek, Connors, Hillori, Keogh, Julia M., Mendes de Oliveira, Edson, Henning, Elana, Poitou-Bernert, Christine, Oppert, Jean-Michel, Tounian, Patrick, Marchelli, Florence, Alili, Rohia, Le Beyec, Johanne, Pépin, Dominique, Lacorte, Jean-Marc, Gottesdiener, Andrew, Bounds, Rebecca, Sharma, Shubh, Folster, Cathy, Henderson, Bart, O'Rahilly, Stephen, Stoner, Elizabeth, Gottesdiener, Keith, Panaro, Brandon L., Cone, Roger D., Clément, Karine, Farooqi, I. Sadaf, Van der Ploeg, Lex H.T.
Publicado no Mol Metab (2017)

A role for the melanocortin 4 receptor in sexual function

por Van der Ploeg, Lex H. T., Martin, William J., Howard, Andrew D., Nargund, Ravi P., Austin, Christopher P., Guan, Xiaoming, Drisko, Jennifer, Cashen, Doreen, Sebhat, Iyassu, Patchett, Arthur A., Figueroa, David J., DiLella, Anthony G., Connolly, Brett M., Weinberg, David H., Tan, Carina P., Palyha, Oksana C., Pong, Sheng-Shung, MacNeil, Tanya, Rosenblum, Charles, Vongs, Aurawan, Tang, Rui, Yu, Hong, Sailer, Andreas W., Fong, Tung Ming, Huang, Cathy, Tota, Michael R., Chang, Ray S., Stearns, Ralph, Tamvakopoulos, Constantin, Christ, George, Drazen, Deborah L., Spar, Brian D., Nelson, Randy J., MacIntyre, D. Euan
Publicado em 2002