Melanocortin 4 Receptor Pathway Dysfunction in Obesity: Patient Stratification Aimed at MC4R Agonist Treatment

CONTEXT: The hypothalamic melanocortin 4 receptor (MC4R) pathway serves a critical role in regulating body weight. Loss of function (LoF) mutations in the MC4R pathway, including mutations in the pro-opiomelanocortin (POMC), prohormone convertase 1 (PCSK1), leptin receptor (LEPR), orMC4R genes, have...

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Detaylı Bibliyografya
Yayımlandı:J Clin Endocrinol Metab
Asıl Yazarlar: Ayers, Kristin L, Glicksberg, Benjamin S, Garfield, Alastair S, Longerich, Simonne, White, Joseph A, Yang, Pengwei, Du, Lei, Chittenden, Thomas W, Gulcher, Jeffery R, Roy, Sophie, Fiedorek, Fred, Gottesdiener, Keith, Cohen, Sarah, North, Kari E, Schadt, Eric E, Li, Shuyu D, Chen, Rong, Van der Ploeg, Lex H T
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Endocrine Society 2018
Konular:
Clinical Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7263790/
https://ncbi.nlm.nih.gov/pubmed/29726959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2018-00258
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