Cholinesterase Inhibitor Therapy in Alzheimer’s: The limits and tolerability of Irreversible CNS-selective Acetylcholinesterase Inhibition in Primates

Por Moss, Donald E., Perez, Ruth G., Kobayashi, Haruo
Publicado no J Alzheimers Dis (2017)

The contribution of alpha synuclein to neuronal survival and function – Implications for Parkinson's disease

Por Benskey, Matthew J., Perez, Ruth G., Manfredsson, Fredric P.
Publicado no J Neurochem (2016)

APP independent and dependent effects on neurite outgrowth are modulated by the receptor associated protein, RAP

Por Billnitzer, Andrew J., Barskaya, Irina, Yin, Cailing, Perez, Ruth G.
Publicado em 2012

14-3-3ζ Contributes to Tyrosine Hydroxylase Activity in MN9D Cells: LOCALIZATION OF DOPAMINE REGULATORY PROTEINS TO MITOCHONDRIA

Por Wang, Jian, Lou, Haiyan, Pedersen, Courtney J., Smith, Amanda D., Perez, Ruth G.
Publicado em 2009

α-SYNUCLEIN AGGREGATION ALTERS TYROSINE HYDROXYLASE PHOSPHORYLATION AND IMMUNOREACTIVITY: LESSONS FROM VIRAL TRANSDUCTION OF KNOCKOUT MICE

Por Alerte, Tshianda N. M., Akinfolarin, Akinwande A., Friedrich, Emily E., Mader, Samantha A., Hong, Chang-Sook, Perez, Ruth G.
Publicado em 2008

Novel FTY720-Based Compounds Stimulate Neurotrophin Expression and Phosphatase Activity in Dopaminergic Cells

Por Vargas-Medrano, Javier, Krishnamachari, Sesha, Villanueva, Ernesto, Godfrey, Wesley H., Lou, Haiyan, Chinnasamy, Ramesh, Arterburn, Jeffrey B., Perez, Ruth G.
Publicado em 2014

Non-motor parkinsonian pathology in aging A53T α-Synuclein mice is associated with progressive synucleinopathy and altered enzymatic function

Por Farrell, Kaitlin F, Krishnamachari, Sesha, Villanueva, Ernesto, Lou, Haiyan, Alerte, Tshianda N M, Peet, Eloise, Drolet, Robert E, Perez, Ruth G
Publicado no J Neurochem (2014)

Lewy-like aggregation of α-synuclein reduces PP2A activity in vitro and in vivo

Por Wu, Jianjun, Lou, Haiyan, Alerte, Tshianda N. M., Stachowski, Erin K., Chen, Jie, Singleton, Andrew B., Hamilton, Ronald L., Perez, Ruth G.
Publicado em 2012

Preclinical Metabolism, Pharmacokinetics and In Vivo Analysis of New Blood-Brain-Barrier Penetrant Fingolimod Analogues: FTY720-C2 and FTY720-Mitoxy

Por Enoru, Julius O., Yang, Barbara, Krishnamachari, Sesha, Villanueva, Ernesto, DeMaio, William, Watanyar, Adiba, Chinnasamy, Ramesh, Arterburn, Jeffrey B., Perez, Ruth G.
Publicado no PLoS One (2016)

α-Synuclein binds the K(ATP) channel at insulin-secretory granules and inhibits insulin secretion

Por Geng, Xuehui, Lou, Haiyan, Wang, Jian, Li, Lehong, Swanson, Alexandra L., Sun, Ming, Beers-Stolz, Donna, Watkins, Simon, Perez, Ruth G., Drain, Peter
Publicado no Am J Physiol Endocrinol Metab (2011)

FTY720/Fingolimod Reduces Synucleinopathy and Improves Gut Motility in A53T Mice: CONTRIBUTIONS OF PRO-BRAIN-DERIVED NEUROTROPHIC FACTOR (PRO-BDNF) AND MATURE BDNF

Por Vidal-Martínez, Guadalupe, Vargas-Medrano, Javier, Gil-Tommee, Carolina, Medina, David, Garza, Nathan T., Yang, Barbara, Segura-Ulate, Ismael, Dominguez, Samantha J., Perez, Ruth G.
Publicado no J Biol Chem (2016)

Serine 129 Phosphorylation Reduces the Ability of α-Synuclein to Regulate Tyrosine Hydroxylase and Protein Phosphatase 2A in Vitro and in Vivo

Por Lou, Haiyan, Montoya, Susana E., Alerte, Tshianda N. M., Wang, Jian, Wu, Jianjun, Peng, Xiangmin, Hong, Chang-Sook, Friedrich, Emily E., Mader, Samantha A., Pedersen, Courtney J., Marcus, Brian S., McCormack, Alison L., Di Monte, Donato A., Daubner, S. Colette, Perez, Ruth G.
Publicado em 2010

The Protein Alpha-Synuclein: Its Normal Role (in Neurons) and its Role in Disease

Publicado em 2020