Preclinical Metabolism, Pharmacokinetics and In Vivo Analysis of New Blood-Brain-Barrier Penetrant Fingolimod Analogues: FTY720-C2 and FTY720-Mitoxy

Parkinson’s disease (PD) is a neurodegenerative aging disorder in which postmortem PD brain exhibits neuroinflammation, as well as synucleinopathy-associated protein phosphatase 2A (PP2A) enzymatic activity loss. Based on our translational research, we began evaluating the PD-repurposing-potential o...

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Detalhes bibliográficos
Publicado no:PLoS One
Principais autores: Enoru, Julius O., Yang, Barbara, Krishnamachari, Sesha, Villanueva, Ernesto, DeMaio, William, Watanyar, Adiba, Chinnasamy, Ramesh, Arterburn, Jeffrey B., Perez, Ruth G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5017749/
https://ncbi.nlm.nih.gov/pubmed/27611691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0162162
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