Novel FTY720-Based Compounds Stimulate Neurotrophin Expression and Phosphatase Activity in Dopaminergic Cells

[Image: see text] α-Synuclein is a chaperone-like protein implicated in Parkinson’s disease (PD). Among α-synuclein’s normal functions is an ability to bind to and stimulate the activity of the protein phosphatase 2A (PP2A) catalytic subunit in vitro and in vivo. PP2A activity is impaired in PD and...

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Main Authors: Vargas-Medrano, Javier, Krishnamachari, Sesha, Villanueva, Ernesto, Godfrey, Wesley H., Lou, Haiyan, Chinnasamy, Ramesh, Arterburn, Jeffrey B., Perez, Ruth G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4094248/
https://ncbi.nlm.nih.gov/pubmed/25050165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500128g
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