FTY720/Fingolimod Reduces Synucleinopathy and Improves Gut Motility in A53T Mice: CONTRIBUTIONS OF PRO-BRAIN-DERIVED NEUROTROPHIC FACTOR (PRO-BDNF) AND MATURE BDNF

Patients with Parkinson's disease (PD) often have aggregated α-synuclein (aSyn) in enteric nervous system (ENS) neurons, which may be associated with the development of constipation. This occurs well before the onset of classic PD motor symptoms. We previously found that aging A53T transgenic (...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Vidal-Martínez, Guadalupe, Vargas-Medrano, Javier, Gil-Tommee, Carolina, Medina, David, Garza, Nathan T., Yang, Barbara, Segura-Ulate, Ismael, Dominguez, Samantha J., Perez, Ruth G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5034069/
https://ncbi.nlm.nih.gov/pubmed/27528608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.744029
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