FTY720/Fingolimod Reduces Synucleinopathy and Improves Gut Motility in A53T Mice: CONTRIBUTIONS OF PRO-BRAIN-DERIVED NEUROTROPHIC FACTOR (PRO-BDNF) AND MATURE BDNF

Patients with Parkinson's disease (PD) often have aggregated α-synuclein (aSyn) in enteric nervous system (ENS) neurons, which may be associated with the development of constipation. This occurs well before the onset of classic PD motor symptoms. We previously found that aging A53T transgenic (...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Vidal-Martínez, Guadalupe, Vargas-Medrano, Javier, Gil-Tommee, Carolina, Medina, David, Garza, Nathan T., Yang, Barbara, Segura-Ulate, Ismael, Dominguez, Samantha J., Perez, Ruth G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5034069/
https://ncbi.nlm.nih.gov/pubmed/27528608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.744029
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