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Mechanism of Action of Oral Fingolimod (FTY720) in Multiple Sclerosis
Fingolimod (FTY720) is a first-in-class orally bioavailable compound that has shown efficacy in advanced clinical trials for the treatment of multiple sclerosis (MS). In vivo, fingolimod is phosphorylated to form fingolimod-phosphate, which resembles naturally occurring sphingosine 1-phosphate (S1P)...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2859693/ https://ncbi.nlm.nih.gov/pubmed/20061941 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/WNF.0b013e3181cbf825 |
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