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Mechanism of Action of Oral Fingolimod (FTY720) in Multiple Sclerosis

Fingolimod (FTY720) is a first-in-class orally bioavailable compound that has shown efficacy in advanced clinical trials for the treatment of multiple sclerosis (MS). In vivo, fingolimod is phosphorylated to form fingolimod-phosphate, which resembles naturally occurring sphingosine 1-phosphate (S1P)...

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Autors principals: Chun, Jerold, Hartung, Hans-Peter
Format: Artigo
Idioma:Inglês
Publicat: 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859693/
https://ncbi.nlm.nih.gov/pubmed/20061941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/WNF.0b013e3181cbf825
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