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FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system
FTY720 (fingolimod) is a first-in-class sphingosine 1-phosphate (S1P) receptor modulator that was highly effective in Phase II clinical trials for Multiple Sclerosis (MS). FTY720 is phosphorylated in vivo by sphingosine kinase-2 to form the active moiety FTY720-phosphate that binds to four of the fi...
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| Format: | Artigo |
| Language: | Inglês |
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Blackwell Publishing Ltd
2009
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| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2782328/ https://ncbi.nlm.nih.gov/pubmed/19814729 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2009.00451.x |
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