FTY720 Improves Behavior, Increases Brain Derived Neurotrophic Factor and Reduces α-Synuclein Pathology in Parkinsonian GM2+/− Mice

Parkinson’s disease (PD) is a progressive aging disorder that affects millions worldwide, thus, disease-modifying-therapies are urgently needed. PD pathology includes α-synuclein (aSyn) accumulation as synucleinopathy. Loss of GM1 gangliosides occurs in PD brain, which is modeled in GM2 synthase tra...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Neuroscience
Main Authors: Vidal-Martinez, Guadalupe, Najera, Katherine, Miranda, Julie D., Gil-Tommee, Carolina, Yang, Barbara, Vargas-Medrano, Javier, Diaz-Pacheco, Valeria, Perez, Ruth G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6612448/
https://ncbi.nlm.nih.gov/pubmed/31129200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2019.05.029
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados