FTY720-Mitoxy Reduces Synucleinopathy and Neuroinflammation, Restores Behavior and Mitochondria Function, and Increases GDNF Expression In Multiple System Atrophy Mice

Multiple system atrophy (MSA) is a fatal disorder with no effective treatment. MSA pathology is characterized by α-synuclein (aSyn) accumulation in oligodendrocytes, the myelinating glial cells of the central nervous system (CNS). aSyn accumulation in oligodendrocytes forms the pathognomonic glial c...

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Publicado no:Exp Neurol
Main Authors: Vidal-Martinez, Guadalupe, Segura-Ulate, Ismael, Yang, Barbara, Diaz-Pacheco, Valeria, Barragan, Jose A., De-Leon Esquivel, Jocelyn, Chaparro, Stephanie A., Vargas-Medrano, Javier, Perez, Ruth G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8021391/
https://ncbi.nlm.nih.gov/pubmed/31751571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2019.113120
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