Loss of Functional Alpha-Synuclein: A Toxic Event in Parkinson’s Disease?

Por Kanaan, Nicholas M., Manfredsson, Fredric P.
Publicado no J Parkinsons Dis (2012)

AAV9: a potential blood-brain barrier buster

Por Manfredsson, Fredric P, Rising, Aaron C, Mandel, Ronald J
Publicado em 2009

The contribution of alpha synuclein to neuronal survival and function – Implications for Parkinson's disease

Por Benskey, Matthew J., Perez, Ruth G., Manfredsson, Fredric P.
Publicado no J Neurochem (2016)

A Method for Combining RNAscope In Situ Hybridization with Immunohistochemistry in Thick Free-Floating Brain Sections and Primary Neuronal Cultures

Por Grabinski, Tessa M., Kneynsberg, Andrew, Manfredsson, Fredric P., Kanaan, Nicholas M.
Publicado no PLoS One (2015)

Quantitative and semi-quantitative measurements of axonal degeneration in tissue and primary neuron cultures

Por Kneynsberg, Andrew, Collier, Timothy J., Manfredsson, Fredric P., Kanaan, Nicholas M.
Publicado no J Neurosci Methods (2016)

The Role of Parkin in the Differential Susceptibility of Tuberoinfundibular and Nigrostriatal Dopamine Neurons to Acute Toxicant Exposure

Por Benskey, Matthew J., Manfredsson, Fredric P., Lookingland, Keith J., Goudreau, John L.
Publicado no Neurotoxicology (2014)

Is Alpha-Synuclein Loss-of-Function a Contributor to Parkinsonian Pathology? Evidence from Non-human Primates

Por Collier, Timothy J., Redmond, D. Eugene, Steece-Collier, Kathy, Lipton, Jack W., Manfredsson, Fredric P.
Publicado no Front Neurosci (2016)

Striatal Readministration of rAAV Vectors Reveals an Immune Response Against AAV2 Capsids That Can Be Circumvented

Por Peden, Carmen S, Manfredsson, Fredric P, Reimsnider, Sharon K, Poirier, Amy E, Burger, Corinna, Muzyczka, Nicholas, Mandel, Ronald J
Publicado em 2009

The phosphorylation state of Ser-129 in human α-synuclein determines neurodegeneration in a rat model of Parkinson disease

Por Gorbatyuk, Oleg S., Li, Shoudong, Sullivan, Layla F., Chen, Weijun, Kondrikova, Galina, Manfredsson, Fredric P., Mandel, Ronald J., Muzyczka, Nicholas
Publicado em 2008

α-Synuclein Expression in Rat Substantia Nigra Suppresses Phospholipase D2 Toxicity and Nigral Neurodegeneration

Por Gorbatyuk, Oleg S, Li, Shoudong, Nha Nguyen, Frederic, Manfredsson, Fredric P, Kondrikova, Galina, Sullivan, Layla F, Meyers, Craig, Chen, Weijun, Mandel, Ronald J, Muzyczka, Nicholas
Publicado em 2010

Differential sensitivity of cranial and limb motor function to nigrostriatal dopamine depletion

Por Plowman, Emily K., Maling, Nicholas, Rivera, Benjamin J., Larson, Krista, Thomas, Nagheme J., Fowler, Stephen C., Manfredsson, Fredric P., Shrivastav, Rahul, Kleim, Jeffrey A.
Publicado em 2012

α-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation

Por Kang, Seong Su, Zhang, Zhentao, Liu, Xia, Manfredsson, Fredric P., He, Li, Iuvone, P. Michael, Cao, Xuebing, Sun, Yi E., Jin, Lingjing, Ye, Keqiang
Publicado no Proc Natl Acad Sci U S A (2017)

Tight Long-term Dynamic Doxycycline Responsive Nigrostriatal GDNF Using a Single rAAV Vector

Por Manfredsson, Fredric P, Burger, Corinna, Rising, Aaron C, Zuobi-Hasona, Kheir, Sullivan, Layla F, Lewin, Alfred S, Huang, Julia, Piercefield, Emily, Muzyczka, Nicholas, Mandel, Ronald J
Publicado em 2009

In Vivo RNAi-Mediated α-Synuclein Silencing Induces Nigrostriatal Degeneration

Por Gorbatyuk, Oleg S, Li, Shoudong, Nash, Kevin, Gorbatyuk, Marina, Lewin, Alfred S, Sullivan, Layla F, Mandel, Ronald J, Chen, Weijun, Meyers, Craig, Manfredsson, Fredric P, Muzyczka, Nicholas
Publicado em 2010

Targeted Gene Delivery to the Enteric Nervous System Using AAV: A Comparison Across Serotypes and Capsid Mutants

Por Benskey, Matthew J, Kuhn, Nathan C, Galligan, James J, Garcia, Joanna, Boye, Shannon E, Hauswirth, William W, Mueller, Christian, Boye, Sanford L, Manfredsson, Fredric P
Publicado no Mol Ther (2015)

Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons

Por Pathak, Divya, Berthet, Amandine, Bendor, Jacob T., Yu, Katharine, Sellnow, Rhyomi C., Orr, Adam L., Nguyen, Mai K, Edwards, Robert H., Manfredsson, Fredric P., Nakamura, Ken
Publicado no eNeuro (2017)

High-Frequency Stimulation of the Rat Entopeduncular Nucleus Does Not Provide Functional or Morphological Neuroprotection from 6-Hydroxydopamine

Por Fischer, D. Luke, Collier, Timothy J., Cole-Strauss, Allyson, Wohlgenant, Susan L., Lipton, Jack W., Steece-Collier, Kathy, Manfredsson, Fredric P., Kemp, Christopher J., Sortwell, Caryl E.
Publicado no PLoS One (2015)

Impact of age and vector construct on striatal and nigral transgene expression

Por Polinski, Nicole K, Manfredsson, Fredric P, Benskey, Matthew J, Fischer, D Luke, Kemp, Christopher J, Steece-Collier, Kathy, Sandoval, Ivette M, Paumier, Katrina L, Sortwell, Caryl E
Publicado no Mol Ther Methods Clin Dev (2016)

The Longitudinal Transcriptomic Response of the Substantia Nigra to Intrastriatal 6-Hydroxydopamine Reveals Significant Upregulation of Regeneration-Associated Genes

Por Kanaan, Nicholas M., Collier, Timothy J., Cole-Strauss, Allyson, Grabinski, Tessa, Mattingly, Zachary R., Winn, Mary E., Steece-Collier, Kathy, Sortwell, Caryl E., Manfredsson, Fredric P., Lipton, Jack W.
Publicado no PLoS One (2015)

Morphological and Behavioral Impact of AAV2/5-Mediated Overexpression of Human Wildtype Alpha-Synuclein in the Rat Nigrostriatal System

Por Gombash, Sara E., Manfredsson, Fredric P., Kemp, Christopher J., Kuhn, Nathan C., Fleming, Sheila M., Egan, Ann E., Grant, Laura M., Ciucci, Michelle R., MacKeigan, Jeffrey P., Sortwell, Caryl E.
Publicado em 2013