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The phosphorylation state of Ser-129 in human α-synuclein determines neurodegeneration in a rat model of Parkinson disease

Studies have shown that α-synuclein (α-syn) deposited in Lewy bodies in brain tissue from patients with Parkinson disease (PD) is extensively phosphorylated at Ser-129. We used recombinant Adeno-associated virus (rAAV) to overexpress human wild-type (wt) α-syn and two human α-syn mutants with site-d...

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Detalhes bibliográficos
Main Authors: Gorbatyuk, Oleg S., Li, Shoudong, Sullivan, Layla F., Chen, Weijun, Kondrikova, Galina, Manfredsson, Fredric P., Mandel, Ronald J., Muzyczka, Nicholas
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2206610/
https://ncbi.nlm.nih.gov/pubmed/18178617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711053105
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