α-Synuclein Expression in Rat Substantia Nigra Suppresses Phospholipase D2 Toxicity and Nigral Neurodegeneration

We present genetic evidence that an in vivo role of α-synuclein (α-syn) is to inhibit phospholipase D2 (PLD2), an enzyme that is believed to participate in vesicle trafficking, membrane signaling, and both endo- and exocytosis. Overexpression of PLD2 in rat substantia nigra pars compacta (SNc) cause...

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Detalhes bibliográficos
Main Authors: Gorbatyuk, Oleg S, Li, Shoudong, Nha Nguyen, Frederic, Manfredsson, Fredric P, Kondrikova, Galina, Sullivan, Layla F, Meyers, Craig, Chen, Weijun, Mandel, Ronald J, Muzyczka, Nicholas
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951555/
https://ncbi.nlm.nih.gov/pubmed/20664530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.137
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