In Vivo RNAi-Mediated α-Synuclein Silencing Induces Nigrostriatal Degeneration

Two small-interfering RNAs (siRNAs) targeting α-synuclein (α-syn) and three control siRNAs were cloned in an adeno-associated virus (AAV) vector and unilaterally injected into rat substantia nigra pars compacta (SNc). Reduction of α-syn resulted in a rapid (4 week) reduction in the number of tyrosin...

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Detalhes bibliográficos
Main Authors: Gorbatyuk, Oleg S, Li, Shoudong, Nash, Kevin, Gorbatyuk, Marina, Lewin, Alfred S, Sullivan, Layla F, Mandel, Ronald J, Chen, Weijun, Meyers, Craig, Manfredsson, Fredric P, Muzyczka, Nicholas
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2927065/
https://ncbi.nlm.nih.gov/pubmed/20551914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.115
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