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Glucose Regulated Protein 78 Diminishes α-Synuclein Neurotoxicity in a Rat Model of Parkinson Disease

Accumulation of human wild-type (wt) α-synuclein (α-syn) induces neurodegeneration in humans and in experimental rodent models of Parkinson disease (PD). It also leads to endoplasmic reticulum (ER) stress and activation of the unfolded protein response (UPR). We overexpressed glucose regulated prote...

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Detaylı Bibliyografya
Asıl Yazarlar: Gorbatyuk, Marina S, Shabashvili, Arseniy, Chen, Weijun, Meyers, Craig, Sullivan, Layla F, Salganik, Max, Lin, Jonathan H, Lewin, Alfred S, Muzyczka, Nicholas, Gorbatyuk, Oleg S
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2012
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392977/
https://ncbi.nlm.nih.gov/pubmed/22434142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.28
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