Glucose Regulated Protein 78 Diminishes α-Synuclein Neurotoxicity in a Rat Model of Parkinson Disease

Accumulation of human wild-type (wt) α-synuclein (α-syn) induces neurodegeneration in humans and in experimental rodent models of Parkinson disease (PD). It also leads to endoplasmic reticulum (ER) stress and activation of the unfolded protein response (UPR). We overexpressed glucose regulated prote...

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Detalhes bibliográficos
Main Authors: Gorbatyuk, Marina S, Shabashvili, Arseniy, Chen, Weijun, Meyers, Craig, Sullivan, Layla F, Salganik, Max, Lin, Jonathan H, Lewin, Alfred S, Muzyczka, Nicholas, Gorbatyuk, Oleg S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392977/
https://ncbi.nlm.nih.gov/pubmed/22434142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.28
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