Nigrostriatal rAAV-mediated GDNF Overexpression Induces Robust Weight Loss in a Rat Model of Age-related Obesity

Intraventricular administration of glial cell line–derived neurotrophic factor (GDNF) in primate and humans to study Parkinson's disease (PD) has revealed the potential for GDNF to induce weight loss. Our previous data indicate that bilateral continuous hypothalamic GDNF overexpression via reco...

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Bibliografiske detaljer
Main Authors: Manfredsson, Fredric P, Tumer, Nihal, Erdos, Benedek, Landa, Tessa, Broxson, Christopher S, Sullivan, Layla F, Rising, Aaron C, Foust, Kevin D, Zhang, Yi, Muzyczka, Nicholas, Gorbatyuk, Oleg S, Scarpace, Philip J, Mandel, Ronald J
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2009
Fag:
Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835185/
https://ncbi.nlm.nih.gov/pubmed/19277011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.45
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