Striatal Readministration of rAAV Vectors Reveals an Immune Response Against AAV2 Capsids That Can Be Circumvented

Recombinant adeno-associated virus (rAAV) expresses no viral genes after transduction. In addition, because the brain is relatively immunoprivileged, intracranial rAAV transduction may be immunologically benign due to a lack of antigen presentation. However, preexposure to AAV allows neutralizing an...

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Main Authors: Peden, Carmen S, Manfredsson, Fredric P, Reimsnider, Sharon K, Poirier, Amy E, Burger, Corinna, Muzyczka, Nicholas, Mandel, Ronald J
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2009
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Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835093/
https://ncbi.nlm.nih.gov/pubmed/19142181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.284
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