Circulating Anti-Wild-Type Adeno-Associated Virus Type 2 (AAV2) Antibodies Inhibit Recombinant AAV2 (rAAV2)-Mediated, but Not rAAV5-Mediated, Gene Transfer in the Brain

Epidemiological studies report that 80% of the population maintains antibodies (Ab) to wild-type (wt) adeno-associated virus type 2 (AAV2), with 30% expressing neutralizing Ab (NAb). The blood-brain barrier (BBB) provides limited immune privilege to brain parenchyma, and the immune response to recom...

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Detalhes bibliográficos
Main Authors: Peden, Carmen S., Burger, Corinna, Muzyczka, Nicholas, Mandel, Ronald J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC416536/
https://ncbi.nlm.nih.gov/pubmed/15163728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.12.6344-6359.2004
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