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Circulating Anti-Wild-Type Adeno-Associated Virus Type 2 (AAV2) Antibodies Inhibit Recombinant AAV2 (rAAV2)-Mediated, but Not rAAV5-Mediated, Gene Transfer in the Brain

Epidemiological studies report that 80% of the population maintains antibodies (Ab) to wild-type (wt) adeno-associated virus type 2 (AAV2), with 30% expressing neutralizing Ab (NAb). The blood-brain barrier (BBB) provides limited immune privilege to brain parenchyma, and the immune response to recom...

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Udgivet i:J Virol
Principais autores: Peden, Carmen S., Burger, Corinna, Muzyczka, Nicholas, Mandel, Ronald J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2004
Fag:
Gene Therapy
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC416536/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15163728/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.12.6344-6359.2004
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