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Long-term RNAi knockdown of α-synuclein in the adult rat substantia nigra without neurodegeneration
α-Synuclein plays a central role in the pathogenesis of Parkinson’s disease (PD); interventions that decrease its expression appear neuroprotective in PD models. Successful translation of these observations into effective therapies will be dependent on the safety of suppressing α-synuclein expressio...
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| 出版年: | Neurobiol Dis |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6440542/ https://ncbi.nlm.nih.gov/pubmed/30658149 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2019.01.004 |
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