shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson’s disease model

Multiple convergent lines of evidence implicate both α-synuclein (encoded by SCNA) and mitochondrial dysfunction in the pathogenesis of sporadic Parkinson’s disease (PD). Occupational exposure to the mitochondrial complex I inhibitor rotenone increases PD risk; rotenone-exposed rats show systemic mi...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Zharikov, Alevtina D., Cannon, Jason R., Tapias, Victor, Bai, Qing, Horowitz, Max P., Shah, Vipul, El Ayadi, Amina, Hastings, Teresa G., Greenamyre, J. Timothy, Burton, Edward A.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4563670/
https://ncbi.nlm.nih.gov/pubmed/26075822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64502
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