α-Synuclein binds TOM20 and inhibits mitochondrial protein import in Parkinson’s disease

α-Synuclein accumulation and mitochondrial dysfunction have both been strongly implicated in the pathogenesis of Parkinson’s disease (PD), and the two appear to be related. Mitochondrial dysfunction leads to accumulation and oligomerization of α-synuclein, and increased levels of α-synuclein cause m...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Sci Transl Med
Päätekijät: Di Maio, Roberto, Barrett, Paul J., Hoffman, Eric K., Barrett, Caitlyn W., Zharikov, Alevtina, Borah, Anupom, Hu, Xiaoping, McCoy, Jennifer, Chu, Charleen T., Burton, Edward A., Hastings, Teresa G., Greenamyre, J. Timothy
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2016
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016095/
https://ncbi.nlm.nih.gov/pubmed/27280685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaf3634
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