Mitochondrial DNA damage: molecular marker of vulnerable nigral neurons in Parkinson's disease

DNA damage can cause (and result from) oxidative stress and mitochondrial impairment, both of which are implicated in the pathogenesis of Parkinson's disease (PD). We therefore examined the role of mitochondrial DNA (mtDNA) damage in human postmortem brain tissue and in in vivo and in vitro mod...

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Autors principals: Sanders, Laurie H, McCoy, Jennifer, Hu, Xiaoping, Mastroberardino, Pier G, Dickinson, Bryan C, Chang, Christopher J, Chu, Charleen T, Van Houten, Bennett, Timothy Greenamyre, J.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144978/
https://ncbi.nlm.nih.gov/pubmed/24981012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2014.06.014
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