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α-Synuclein binds TOM20 and inhibits mitochondrial protein import in Parkinson’s disease
α-Synuclein accumulation and mitochondrial dysfunction have both been strongly implicated in the pathogenesis of Parkinson’s disease (PD), and the two appear to be related. Mitochondrial dysfunction leads to accumulation and oligomerization of α-synuclein, and increased levels of α-synuclein cause m...
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| Опубликовано в: : | Sci Transl Med |
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| Главные авторы: | , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5016095/ https://ncbi.nlm.nih.gov/pubmed/27280685 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaf3634 |
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