α-Synuclein binds TOM20 and inhibits mitochondrial protein import in Parkinson’s disease

α-Synuclein accumulation and mitochondrial dysfunction have both been strongly implicated in the pathogenesis of Parkinson’s disease (PD), and the two appear to be related. Mitochondrial dysfunction leads to accumulation and oligomerization of α-synuclein, and increased levels of α-synuclein cause m...

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Pubblicato in:Sci Transl Med
Autori principali: Di Maio, Roberto, Barrett, Paul J., Hoffman, Eric K., Barrett, Caitlyn W., Zharikov, Alevtina, Borah, Anupom, Hu, Xiaoping, McCoy, Jennifer, Chu, Charleen T., Burton, Edward A., Hastings, Teresa G., Greenamyre, J. Timothy
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016095/
https://ncbi.nlm.nih.gov/pubmed/27280685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaf3634
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