α-Synuclein binds TOM20 and inhibits mitochondrial protein import in Parkinson’s disease

α-Synuclein accumulation and mitochondrial dysfunction have both been strongly implicated in the pathogenesis of Parkinson’s disease (PD), and the two appear to be related. Mitochondrial dysfunction leads to accumulation and oligomerization of α-synuclein, and increased levels of α-synuclein cause m...

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Publicado en:Sci Transl Med
Main Authors: Di Maio, Roberto, Barrett, Paul J., Hoffman, Eric K., Barrett, Caitlyn W., Zharikov, Alevtina, Borah, Anupom, Hu, Xiaoping, McCoy, Jennifer, Chu, Charleen T., Burton, Edward A., Hastings, Teresa G., Greenamyre, J. Timothy
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016095/
https://ncbi.nlm.nih.gov/pubmed/27280685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaf3634
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