α-Synuclein amplifies cytoplasmic peroxide flux and oxidative stress provoked by mitochondrial inhibitors in CNS dopaminergic neurons in vivo

Convergent evidence implicates impaired mitochondrial function and α-Synuclein accumulation as critical upstream events in the pathogenesis of Parkinson's disease, but comparatively little is known about how these factors interact to provoke neurodegeneration. We previously showed that α-Synucl...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Van Laar, Victor S., Chen, Jianming, Zharikov, Alevtina D., Bai, Qing, Di Maio, Roberto, Dukes, April A., Hastings, Teresa G., Watkins, Simon C., Greenamyre, J. Timothy, St Croix, Claudette M., Burton, Edward A.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7486459/
https://ncbi.nlm.nih.gov/pubmed/32905883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101695
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