Long-term RNAi knockdown of α-synuclein in the adult rat substantia nigra without neurodegeneration

α-Synuclein plays a central role in the pathogenesis of Parkinson’s disease (PD); interventions that decrease its expression appear neuroprotective in PD models. Successful translation of these observations into effective therapies will be dependent on the safety of suppressing α-synuclein expressio...

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Bibliografiske detaljer
Udgivet i:Neurobiol Dis
Main Authors: Zharikov, Alevtina, Bai, Qing, De Miranda, Briana R., Van Laar, Amber, Greenamyre, J. Timothy, Burton, Edward A.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6440542/
https://ncbi.nlm.nih.gov/pubmed/30658149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2019.01.004
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