α-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation

The abnormal aggregation of fibrillar α-synuclein in Lewy bodies plays a critical role in the pathogenesis of Parkinson’s disease. However, the molecular mechanisms regulating α-synuclein pathological effects are incompletely understood. Here we show that α-synuclein binds phosphoinositide-3 kinase...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Kang, Seong Su, Zhang, Zhentao, Liu, Xia, Manfredsson, Fredric P., He, Li, Iuvone, P. Michael, Cao, Xuebing, Sun, Yi E., Jin, Lingjing, Ye, Keqiang
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2017
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5293033/
https://ncbi.nlm.nih.gov/pubmed/28096359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1618627114
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