TrkB neurotrophic activities are blocked by α-synuclein, triggering dopaminergic cell death in Parkinson’s disease

BDNF/TrkB neurotrophic signaling is essential for dopaminergic neuronal survival, and the activities are reduced in the substantial nigra (SN) of Parkinson’s disease (PD). However, whether α-Syn (alpha-synuclein) aggregation, a hallmark in the remaining SN neurons in PD, accounts for the neurotrophi...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kang, Seong Su, Zhang, Zhentao, Liu, Xia, Manfredsson, Fredric P., Benskey, Matthew J., Cao, Xuebing, Xu, Jun, Sun, Yi E., Ye, Keqiang
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635931/
https://ncbi.nlm.nih.gov/pubmed/28923922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1713969114
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