Delta-secretase-cleaved Tau antagonizes TrkB neurotrophic signalings, mediating Alzheimer’s disease pathologies

BDNF, an essential trophic factor implicated in synaptic plasticity and neuronal survival, is reduced in Alzheimer’s disease (AD). BDNF deficiency’s association with Tau pathology in AD is well documented. However, the molecular mechanisms accounting for these events remain incompletely understood....

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Xiang, Jie, Wang, Zhi-Hao, Ahn, Eun Hee, Liu, Xia, Yu, Shan-Ping, Manfredsson, Fredric P., Sandoval, Ivette M., Ju, Gong, Wu, Shengxi, Ye, Keqiang
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6500177/
https://ncbi.nlm.nih.gov/pubmed/31004063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1901348116
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