Optimized TrkB Agonist Ameliorates Alzheimer’s Disease Pathologies and Improves Cognitive Functions via Inhibiting Delta-Secretase

[Image: see text] BDNF/TrkB neurotropic pathway, essential for neural synaptic plasticity and survival, is deficient in neurodegenerative diseases including Alzheimer’s disease (AD). Our previous works support that BDNF diminishes AD pathologies by inhibiting delta-secretase, a crucial age-dependent...

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Detalhes bibliográficos
Publicado no:ACS Chem Neurosci
Main Authors: Chen, Chun, Ahn, Eun H., Liu, Xia, Wang, Zhi-Hao, Luo, Shilin, Liao, Jianming, Ye, Keqiang
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2021
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8269693/
https://ncbi.nlm.nih.gov/pubmed/34106682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.1c00181
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