A delta-secretase-truncated APP fragment activates CEBPB, mediating Alzheimer’s disease pathologies

Amyloid-β precursor protein (APP) is sequentially cleaved by secretases and generates amyloid-β, the major components in senile plaques in Alzheimer’s disease. APP is upregulated in human Alzheimer’s disease brains. However, the molecular mechanism of how APP contributes to Alzheimer’s disease patho...

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Detalles Bibliográficos
Publicado en:Brain
Main Authors: Yao, Yinan, Kang, Seong Su, Xia, Yiyuan, Wang, Zhi-Hao, Liu, Xia, Muller, Thorsten, Sun, Yi E, Ye, Keqiang
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2021
Assuntos:
Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8320270/
https://ncbi.nlm.nih.gov/pubmed/33880508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awab062
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