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A delta-secretase-truncated APP fragment activates CEBPB, mediating Alzheimer’s disease pathologies
Amyloid-β precursor protein (APP) is sequentially cleaved by secretases and generates amyloid-β, the major components in senile plaques in Alzheimer’s disease. APP is upregulated in human Alzheimer’s disease brains. However, the molecular mechanism of how APP contributes to Alzheimer’s disease patho...
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| Publicado no: | Brain |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8320270/ https://ncbi.nlm.nih.gov/pubmed/33880508 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awab062 |
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