Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease

δ-secretase, also known as asparagine endopeptidase (AEP) or legumain, is a lysosomal cysteine protease that cleaves both amyloid precursor protein (APP) and tau, mediating the amyloid-β and tau pathology in Alzheimer's disease (AD). Here we report the therapeutic effect of an orally bioactive...

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Udgivet i:Nat Commun
Main Authors: Zhang, Zhentao, Obianyo, Obiamaka, Dall, Elfriede, Du, Yuhong, Fu, Haian, Liu, Xia, Kang, Seong Su, Song, Mingke, Yu, Shan-Ping, Cabrele, Chiara, Schubert, Mario, Li, Xiaoguang, Wang, Jian-Zhi, Brandstetter, Hans, Ye, Keqiang
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5378956/
https://ncbi.nlm.nih.gov/pubmed/28345579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14740
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