Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease

The age-dependent deposition of amyloid-β peptides, derived from amyloid precursor protein (APP), is a neuropathological hallmark of Alzheimer's disease (AD). Despite age being the greatest risk factor for AD, the molecular mechanisms linking ageing to APP processing are unknown. Here we show t...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Zhang, Zhentao, Song, Mingke, Liu, Xia, Su Kang, Seong, Duong, Duc M., Seyfried, Nicholas T., Cao, Xuebing, Cheng, Liming, Sun, Yi E., Ping Yu, Shan, Jia, Jianping, Levey, Allan I., Ye, Keqiang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4659940/
https://ncbi.nlm.nih.gov/pubmed/26549211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9762
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