C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer’s disease

Delta-secretase cleaves both APP and Tau to mediate the formation of amyloid plaques and neurofibrillary tangle in Alzheimer’s disease (AD). However, how aging contributes to an increase in delta-secretase expression and AD pathologies remains unclear. Here we show that a CCAAT-enhancer-binding prot...

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Vydáno v:Nat Commun
Hlavní autoři: Wang, Zhi-Hao, Gong, Ke, Liu, Xia, Zhang, Zhentao, Sun, Xiaoou, Wei, Zheng Zachory, Yu, Shan Ping, Manfredsson, Fredric P., Sandoval, Ivette M., Johnson, Peter F., Jia, Jianping, Wang, Jian-Zhi, Ye, Keqiang
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5934399/
https://ncbi.nlm.nih.gov/pubmed/29725016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04120-z
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