Delta-secretase Phosphorylation by SRPK2 Enhances its Enzymatic Activity, Provoking the Pathogenesis in Alzheimer’s Disease

Delta-secretase, a lysosomal asparagine endopeptidase (AEP), simultaneously cleaves both APP and Tau, controlling the onset of pathogenesis of Alzheimer’s disease (AD). However, how this protease is post-translationally regulated remains unclear. Here we report that Serine-arginine protein kinase 2...

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Detalhes bibliográficos
Publicado no:Mol Cell
Principais autores: Wang, Zhi-Hao, Liu, Pai, Liu, Xia, Manfredsson, Fredric P., Sandoval, Ivette M., Ping Yu, Shan, Wang, Jian-Zhi, Ye, Keqiang
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5753427/
https://ncbi.nlm.nih.gov/pubmed/28826672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.07.018
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