Delta-secretase (AEP) mediates tau-splicing imbalance and accelerates cognitive decline in tauopathies

SRPK2 is abnormally activated in tauopathies including Alzheimer’s disease (AD). SRPK2 is known to play an important role in pre–mRNA splicing by phosphorylating SR-splicing factors. Dysregulation of tau exon 10 pre–mRNA splicing causes pathological imbalances in 3R- and 4R-tau, leading to neurodege...

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發表在:J Exp Med
Main Authors: Wang, Zhi-Hao, Liu, Pai, Liu, Xia, Yu, Shan Ping, Wang, Jian-Zhi, Ye, Keqiang
格式: Artigo
語言:Inglês
出版: Rockefeller University Press 2018
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Research Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6279401/
https://ncbi.nlm.nih.gov/pubmed/30373880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20180539
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