Delta-secretase (AEP) mediates tau-splicing imbalance and accelerates cognitive decline in tauopathies

SRPK2 is abnormally activated in tauopathies including Alzheimer’s disease (AD). SRPK2 is known to play an important role in pre–mRNA splicing by phosphorylating SR-splicing factors. Dysregulation of tau exon 10 pre–mRNA splicing causes pathological imbalances in 3R- and 4R-tau, leading to neurodege...

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Udgivet i:J Exp Med
Main Authors: Wang, Zhi-Hao, Liu, Pai, Liu, Xia, Yu, Shan Ping, Wang, Jian-Zhi, Ye, Keqiang
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2018
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6279401/
https://ncbi.nlm.nih.gov/pubmed/30373880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20180539
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