Delta-secretase (AEP) mediates tau-splicing imbalance and accelerates cognitive decline in tauopathies

SRPK2 is abnormally activated in tauopathies including Alzheimer’s disease (AD). SRPK2 is known to play an important role in pre–mRNA splicing by phosphorylating SR-splicing factors. Dysregulation of tau exon 10 pre–mRNA splicing causes pathological imbalances in 3R- and 4R-tau, leading to neurodege...

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Dades bibliogràfiques
Publicat a:J Exp Med
Autors principals: Wang, Zhi-Hao, Liu, Pai, Liu, Xia, Yu, Shan Ping, Wang, Jian-Zhi, Ye, Keqiang
Format: Artigo
Idioma:Inglês
Publicat: Rockefeller University Press 2018
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6279401/
https://ncbi.nlm.nih.gov/pubmed/30373880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20180539
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