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Delta-secretase (AEP) mediates tau-splicing imbalance and accelerates cognitive decline in tauopathies
SRPK2 is abnormally activated in tauopathies including Alzheimer’s disease (AD). SRPK2 is known to play an important role in pre–mRNA splicing by phosphorylating SR-splicing factors. Dysregulation of tau exon 10 pre–mRNA splicing causes pathological imbalances in 3R- and 4R-tau, leading to neurodege...
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| Publicado no: | J Exp Med |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Rockefeller University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6279401/ https://ncbi.nlm.nih.gov/pubmed/30373880 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20180539 |
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