Optimized TrkB Agonist Ameliorates Alzheimer’s Disease Pathologies and Improves Cognitive Functions via Inhibiting Delta-Secretase

[Image: see text] BDNF/TrkB neurotropic pathway, essential for neural synaptic plasticity and survival, is deficient in neurodegenerative diseases including Alzheimer’s disease (AD). Our previous works support that BDNF diminishes AD pathologies by inhibiting delta-secretase, a crucial age-dependent...

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Bibliographic Details
Published in:ACS Chem Neurosci
Main Authors: Chen, Chun, Ahn, Eun H., Liu, Xia, Wang, Zhi-Hao, Luo, Shilin, Liao, Jianming, Ye, Keqiang
Format: Artigo
Language:Inglês
Published: American Chemical Society 2021
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8269693/
https://ncbi.nlm.nih.gov/pubmed/34106682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.1c00181
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