Optimized TrkB Agonist Ameliorates Alzheimer’s Disease Pathologies and Improves Cognitive Functions via Inhibiting Delta-Secretase

[Image: see text] BDNF/TrkB neurotropic pathway, essential for neural synaptic plasticity and survival, is deficient in neurodegenerative diseases including Alzheimer’s disease (AD). Our previous works support that BDNF diminishes AD pathologies by inhibiting delta-secretase, a crucial age-dependent...

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Publicado en:ACS Chem Neurosci
Autores principales: Chen, Chun, Ahn, Eun H., Liu, Xia, Wang, Zhi-Hao, Luo, Shilin, Liao, Jianming, Ye, Keqiang
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2021
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8269693/
https://ncbi.nlm.nih.gov/pubmed/34106682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.1c00181
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