The Longitudinal Transcriptomic Response of the Substantia Nigra to Intrastriatal 6-Hydroxydopamine Reveals Significant Upregulation of Regeneration-Associated Genes

We hypothesized that the study of gene expression at 1, 2, 4, 6 and 16 weeks in the substantia nigra (SN) after intrastriatal 6-OHDA in the Sprague-Dawley rat (rattus norvegicus) would identify cellular responses during the degenerative process that could be axoprotective. Specifically, we hypothesi...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Kanaan, Nicholas M., Collier, Timothy J., Cole-Strauss, Allyson, Grabinski, Tessa, Mattingly, Zachary R., Winn, Mary E., Steece-Collier, Kathy, Sortwell, Caryl E., Manfredsson, Fredric P., Lipton, Jack W.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4439078/
https://ncbi.nlm.nih.gov/pubmed/25992874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0127768
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